Brighton Collaboration updates interim case definition of thrombosis and thrombocytopenia syndrome

The Brighton Collaboration released an update to its provisional case definition of thrombosis and thrombocytopenia syndrome (TTS). The update recognizes the possibility that patients with this condition could be part of a spectrum that may include thrombocytopenia alone, as well as patients suffering from thrombosis without thrombocytopenia.

Because heparin can cause heparin-induced thrombosis and thrombocytopenia syndrome (HITTS) which is clinically similar to TTS, the updated definition of TTS includes how to address exposure to heparin in identifying cases, and its stratification based on whether the administration of heparin occurred within 100 days after the onset of symptoms, while also taking into account that exposure to heparin could have occurred before or after administration of the vaccine.

Source: https://brightoncollaboration.us/thrombosis-with-thrombocytopenia-syndrome-interimcase-definition/